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Novavax COVID-19 vaccine works, but less so against variants

Novavax COVID-19 vaccine works, but less so against variants
HOSPITALS LIKE THIS ONE. >> IS A STORY WE HAVE BEEN COVERING CLOSELY, AND ONGOING EFFORT BY GAITHERSBURG BASED NOVAVAX AND ITS RACE FOR A COVID-19 VACCINE. NOVAVAX WAS THRUST INTO THE NATIONAL SPOTLIGHT AFTER BEING CHOSEN TO PARTICIPATE IN THE WHITE HOUSE바카라 게임 웹사이트S OPERATION WARP SPEED AND GIVEN A 1.6 BILLION DOLLAR GRANT FOR RESEARCH. FRIDAY AT THE CDC바카라 게임 웹사이트S ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES MEETING, WE GOT A BETTER PICTURE AS TO HOW NOVAVAX바카라 게임 웹사이트S RESEARCH IS GOIN WHEN IT COMES TO STAGE ONE CONCLUSIONS, DOCTORS FOUND 2 DOSES OF THE VACCINE ADMINISTERED 21 DAYS APART WERE SUPERIOR TO JUST A SINGLE DOSE AND THAT THE COMMON SIDE EFFECTS INCLUDED HEADACHE. FATIGUE AND MYALGIA. STAGE TWO, WHICH IS STILL IN PROGRESS, HAS YIELDED SOME SIMILAR RESULTS FINDINGS SHOW THE SAME SIDE EFFECTS AND AGAIN TWO DOSES APPEAR BETTER THAN ONE. >> IT VALIDATES WHAT WE바카라 게임 웹사이트RE DOING. PEOPLE BELIEVE THAT WE HAVE A GOOD VACCINE AND THAT NEEDS TO BE SUPPORTED AND BROUGHT TO THE PUBLIC. BACK IN JULY, WE SPOKE WITH JIM YOUNG, CHAIRMAN OF NOVAVAX, WHO EXPRESSED GREAT CONFIDENCE IN HIS TEAM AND IT SEEMS TO BE COMING TO FRUITION. >> WHILE A SEPARATE PHASE THREE IS UNDERWAY IN THE U.K., IN THE US AND MEXICO, BY THE END OF THE MONTH, A PLACEBO CONTROLLED STUDY WILL BEGIN USING THE TWO DOSE METHOD. THE GOAL IS TO TEST UP TO 30,000 ADULTS OF VARIOUS AGES RISK CATAGORIES AND RACES. DATA FROM THE PHASE THREE TRIAL IS EXPECTED AS SOON AS EARLY FIRST QUARTER 2021. AROUND JANUARY. FOR A CLOSER LOOK AT TODAY바카라 게임 웹사이트S CDC MEETING, VISIT THE WBALTV.COM AND MOBILE APP LIVE IN
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Novavax COVID-19 vaccine works, but less so against variants
Novavax Inc. said Thursday that its COVID-19 vaccine appears 89% effective based on early findings from a British study and that it also seems to work 바카라 게임 웹사이트 though not as well 바카라 게임 웹사이트 against new mutated versions of the virus circulating in that country and South Africa.The announcement comes amid worry about whether a variety of vaccines being rolled out around the world will be strong enough to protect against worrisome new variants 바카라 게임 웹사이트 and as the world desperately needs new types of shots to boost scarce supplies.The study of 15,000 people in Britain is still underway. But an interim analysis found 62 participants so far have been diagnosed with COVID-19 바카라 게임 웹사이트 only six of them in the group that got vaccine and the rest who received dummy shots.The infections occurred at a time when Britain was experiencing a jump in COVID-19 caused by a more contagious variant. A preliminary analysis found over half of the trial participants who became infected had the mutated version. The numbers are very small, but Novavax said they suggest the vaccine is nearly 96% effective against the older coronavirus and nearly 86% effective against the new variant. The findings are based on cases that occurred at least a week after the second dose.바카라 게임 웹사이트Both those numbers are dramatic demonstrations of the ability of our vaccine to develop a very potent immune response,바카라 게임 웹사이트 Novavax CEO Stanley Erck said in a call with investors late Thursday.Scientists have been even more worried about a variant first discovered in South Africa that carries different mutations. Results from a smaller Novavax study in that country suggests the vaccine does work but not nearly as well as it does against the variant from Britain.The South African study included some volunteers with HIV. Among the HIV-negative volunteers, the vaccine appears 60% effective. Including volunteers with HIV, overall the protection was 49%, the company said. While genetic testing is still underway, so far about 90% of the COVID-19 illnesses found in the South African study appear due to the new mutant.바카라 게임 웹사이트These are good results. There is reason to be optimistic바카라 게임 웹사이트 about the 60% effectiveness, said Glenda Gray, head of the South African Medical Research Council. Even against the new variant that now causes more than 90% of new cases in that country, 바카라 게임 웹사이트we바카라 게임 웹사이트re still seeing vaccine efficacy,바카라 게임 웹사이트 she said.More concerning is what the study showed about a totally different question 바카라 게임 웹사이트 the chances of people getting COVID-19 a second time, said the leader of the South African study, Shabir Madhi of the University of the Witwatersrand in Johannesburg. Tests suggested that nearly a third of study participants had been previously infected, yet rates of new infections in the placebo group were similar. 바카라 게임 웹사이트Past infection with early variants of the virus in South Africa does not protect바카라 게임 웹사이트 against infection with the new one, he said. 바카라 게임 웹사이트There doesn바카라 게임 웹사이트t seem to be any protection derived.바카라 게임 웹사이트Novavax said it needs some additional data before it can seek British authorization for the vaccine바카라 게임 웹사이트s use, sometime in the next month or so. A larger study in the U.S. and Mexico has enrolled slightly over half of the needed 30,000 volunteers. Novavax said it's not clear if the Food and Drug Administration will need data from that study, too, before deciding whether to allow U.S. use.Meanwhile, it is starting to develop a version of the vaccine that could more specifically target the mutations found in South Africa, in case health authorities eventually decide that updated dosing is needed.Vaccines against COVID-19 train the body to recognize the new coronavirus, mostly the spike protein that coats it. But the Novavax candidate is made differently than the first shots being used. Called a recombinant protein vaccine, the Maryland company uses genetic engineering to grow harmless copies of the coronavirus spike protein in insect cells. Scientists extract and purify the protein and then mix in an immune-boosting chemical.___AP Medical Writer Marilynn Marchione contributed.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute바카라 게임 웹사이트s Department of Science Education. The AP is solely responsible for all content.

Novavax Inc. said Thursday that its COVID-19 vaccine appears 89% effective based on early findings from a British study and that it also seems to work 바카라 게임 웹사이트 though not as well 바카라 게임 웹사이트 against new mutated versions of the virus circulating in that country and South Africa.

The announcement comes amid worry about whether a variety of vaccines being rolled out around the world will be strong enough to protect against worrisome new variants 바카라 게임 웹사이트 and as the world desperately needs new types of shots to boost scarce supplies.

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The study of 15,000 people in Britain is still underway. But an interim analysis found 62 participants so far have been diagnosed with COVID-19 바카라 게임 웹사이트 only six of them in the group that got vaccine and the rest who received dummy shots.

The infections occurred at a time when Britain was experiencing a jump in COVID-19 caused by a more contagious variant. A preliminary analysis found over half of the trial participants who became infected had the mutated version. The numbers are very small, but Novavax said they suggest the vaccine is nearly 96% effective against the older coronavirus and nearly 86% effective against the new variant. The findings are based on cases that occurred at least a week after the second dose.

바카라 게임 웹사이트Both those numbers are dramatic demonstrations of the ability of our vaccine to develop a very potent immune response,바카라 게임 웹사이트 Novavax CEO Stanley Erck said in a call with investors late Thursday.

Scientists have been even more worried about a variant first discovered in South Africa that carries different mutations. Results from a smaller Novavax study in that country suggests the vaccine does work but not nearly as well as it does against the variant from Britain.

The South African study included some volunteers with HIV. Among the HIV-negative volunteers, the vaccine appears 60% effective. Including volunteers with HIV, overall the protection was 49%, the company said. While genetic testing is still underway, so far about 90% of the COVID-19 illnesses found in the South African study appear due to the new mutant.

바카라 게임 웹사이트These are good results. There is reason to be optimistic바카라 게임 웹사이트 about the 60% effectiveness, said Glenda Gray, head of the South African Medical Research Council. Even against the new variant that now causes more than 90% of new cases in that country, 바카라 게임 웹사이트we바카라 게임 웹사이트re still seeing vaccine efficacy,바카라 게임 웹사이트 she said.

More concerning is what the study showed about a totally different question 바카라 게임 웹사이트 the chances of people getting COVID-19 a second time, said the leader of the South African study, Shabir Madhi of the University of the Witwatersrand in Johannesburg. Tests suggested that nearly a third of study participants had been previously infected, yet rates of new infections in the placebo group were similar.

바카라 게임 웹사이트Past infection with early variants of the virus in South Africa does not protect바카라 게임 웹사이트 against infection with the new one, he said. 바카라 게임 웹사이트There doesn바카라 게임 웹사이트t seem to be any protection derived.바카라 게임 웹사이트

Novavax said it needs some additional data before it can seek British authorization for the vaccine바카라 게임 웹사이트s use, sometime in the next month or so. A larger study in the U.S. and Mexico has enrolled slightly over half of the needed 30,000 volunteers. Novavax said it's not clear if the Food and Drug Administration will need data from that study, too, before deciding whether to allow U.S. use.

Meanwhile, it is starting to develop a version of the vaccine that could more specifically target the mutations found in South Africa, in case health authorities eventually decide that updated dosing is needed.

Vaccines against COVID-19 train the body to recognize the new coronavirus, mostly the spike protein that coats it. But the Novavax candidate is made differently than the first shots being used. Called a recombinant protein vaccine, the Maryland company uses genetic engineering to grow harmless copies of the coronavirus spike protein in insect cells. Scientists extract and purify the protein and then mix in an immune-boosting chemical.

___

AP Medical Writer Marilynn Marchione contributed.

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute바카라 게임 웹사이트s Department of Science Education. The AP is solely responsible for all content.