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Immunity to coronavirus lingers for months, study finds

Immunity to coronavirus lingers for months, study finds
KIM: WELL, DEBORAH, DOCTORS SAY, AS WITH ANY INFECTIOUS DISEASE, CERTAIN PEOPLE ARE MORE OR LESS LIKELY TO CONTRACT COVID, BASED ON A NUMBER OF FACTORS, AND THEY바카라 게임 웹사이트RE STARTING TO NARROW DOWN WHO THOSE GROUPS ARE. ONLY A QUARTER OF PEOPLE LIVING IN THE SAME HOUSE HOLD AS COVID PATIENTS WILL ALSO GET INFECTED, EITHER BECAUSE THEIR EXPOSURE IS LOWER OR THEY HAVE T-CELL IMMUNITY. DR. ADALJA: THAT T CELL IMMUNITY MIGHT ARISE, BECAUSE THERE ARE FOUR OTHER CORONAVIRUSES THAT CAUSE ABOUT 25% OF OUR COMMON COLDS, AND SOME OF THAT T-CELL IMMUNITY MIGHT BE CROSS REACTIVE. KIM: THERE IS ALSO SOME EVIDENCE EMERGING THAT BLOOD TYPE PLAYS A ROLE IN CONTRACTING THE DISEASE. DR. ADALJA SAYS, THOUGH NOT CONCLUSIVE, RESEARCHERS ARE FINDING THAT PEOPLE WITH TYPE O BLOOD ARE LESS LIKELY TO GET COVID OR HAVE A SEVERE CASE. DR. ADALJA: WE DO KNOW THAT THE IMMUNE SYSTEM IS INTRICATELY INVOLVED WITH BLOOD TYPE, AND THERE LIKELY IS SOME DIFFERENCE THERE, BECAUSE WHEN PEOPLE HAVE TYPE O BLOOD, THEY HAVE ANTIBODIES AGAINST TYPE A AND TYPE B. THAT MAY PLAY SOME ROLE IN HOW THE VIRUS INTERACTS WITH THE RECEPTORS THAT IT HAS TO BIND TO KIM: RESEARCHERS ARE ALSO LOOKING AT VIRAL LOAD. GENERALLY THE HIGHER THE VIRAL LOAD, THE MORE SEVERE AND MORE CONTAGIOUS YOU MAY BE TO OTHERS, AND THAT IS WHY IT IS ESPECIALLY IMPORTANT TO WEAR A MASK. DR. ADALJA: BECAUSE IF YOU GET INFECTED DESPITE A FACE COVERING YOU바카라 게임 웹사이트RE PROBABLY GETTING INFECTED , WITH A LOWER VIRAL LOAD, BECAUSE SOME OF THOSE PARTICLES ARE GETTING BLOCKED.
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Immunity to coronavirus lingers for months, study finds
Related video above: Info about how coronavirus spreads, who's most at risk emergesImmunity to COVID-19 infection lingers for at least five months, researchers reported 바카라 게임 웹사이트 and probably longer than that.While the report may seem confusing and contradictory to a similar report out of Britain this week, it really isn't. People's bodies produce an army of immune compounds in response to an infection. Some are overwhelming at first, dying off quickly, while others build more slowly.The new report shows 90% of people who recover from COVID-19 infections keep a stable antibody response."While some reports have come out saying antibodies to this virus go away quickly, we have found just the opposite 바카라 게임 웹사이트 that more than 90% of people who were mildly or moderately ill produce an antibody response strong enough to neutralize the virus, and the response is maintained for many months," Florian Krammer, a professor of vaccinology at the Icahn School of Medicine at Mount Sinai, who led the study team, said in a statement."This is essential for effective vaccine development."The team looked at the antibody responses of more than 30,000 people who tested positive for COVID-19 at Mount Sinai's Health System in New York between March and October. They characterized their antibody responses as low, moderate or high. More than 90% had moderate to high levels, or titers, of antibodies to the spike protein of the virus 바카라 게임 웹사이트 the structure it uses to grapple the cells it infects.They then closely studied 121 patients who recovered and donated their plasma 바카라 게임 웹사이트 once three months after they first developed symptoms and again five months later.They saw a drop-off in some antibodies. But others persisted, they reported in the journal Science."The serum antibody titer we measured in individuals initially were likely produced by plasmablasts, cells that act as first responders to an invading virus and come together to produce initial bouts of antibodies whose strength soon wanes," said Dr. Ania Wajnberg, director of Clinical Antibody Testing at the Mount Sinai Hospital."The sustained antibody levels that we subsequently observed are likely produced by long-lived plasma cells in the bone marrow. This is similar to what we see in other viruses and likely means they are here to stay. We will continue to follow this group over time to see if these levels remain stable as we suspect and hope they will."Antibodies are not the only protection the immune system musters against infection, but they are an important first line of defense."Although this cannot provide conclusive evidence that these antibody responses protect from reinfection, we believe it is very likely that they will decrease the odds ratio of reinfection," the team wrote.COVID-19 has been around for a only little under a year, so scientists are still learning about it. Stories of people becoming infected more than once are mostly anecdotal and few and far between.There's obvious concern about this. It would be far better for getting rid of the pandemic if people developed permanent immunity to the virus after an infection. And, of course, immunity would be vital for a vaccine to work well.It happens with other viruses. Measles is an example. One bout of measles usually leaves someone immune for life, an effect known as sterilizing immunity. The same was true for smallpox, before that virus was eradicated in the 1970s by a global vaccination campaign. And proper vaccination against measles and smallpox completely protects against infection.But respiratory viruses such as influenza are trickier. People can catch flu over and over again and flu vaccines generally provide only partial protection against infection and severe disease. Part of that is due to flu's tendency to mutate.Coronaviruses seem to fall in between. They can cause the common cold, but because they are not usually deadly, they are not as well studied. Until COVID-19's deadly cousin SARS came along, there was little interest in coronaviruses.Still, there is evidence that people can and do develop some immunity to coronaviruses."We know from work with common human coronaviruses that neutralizing antibodies are induced, and these antibodies can last for years and provide protection from reinfection or attenuate disease, even if individuals get reinfected," Wajnberg and colleagues wrote."It is still unclear if infection with SARS-CoV-2 in humans protects from reinfection and for how long."The next important step, they said, will be to establish what are known as correlates of protection. These are compounds that can be measured in the blood that will tell doctors whether someone is immune 바카라 게임 웹사이트 so that it won't be necessary to wait and see if they get infected again after one bout, or after getting a vaccine.

Related video above: Info about how coronavirus spreads, who's most at risk emerges

Immunity to COVID-19 infection lingers for at least five months, researchers reported 바카라 게임 웹사이트 and probably longer than that.

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While the report may seem confusing and contradictory to a similar report out of Britain this week, it really isn't. People's bodies produce an army of immune compounds in response to an infection. Some are overwhelming at first, dying off quickly, while others build more slowly.

The new report shows 90% of people who recover from COVID-19 infections keep a stable antibody response.

"While some reports have come out saying antibodies to this virus go away quickly, we have found just the opposite 바카라 게임 웹사이트 that more than 90% of people who were mildly or moderately ill produce an antibody response strong enough to neutralize the virus, and the response is maintained for many months," Florian Krammer, a professor of vaccinology at the Icahn School of Medicine at Mount Sinai, who led the study team, said in a statement.

"This is essential for effective vaccine development."

The team looked at the antibody responses of more than 30,000 people who tested positive for COVID-19 at Mount Sinai's Health System in New York between March and October. They characterized their antibody responses as low, moderate or high. More than 90% had moderate to high levels, or titers, of antibodies to the spike protein of the virus 바카라 게임 웹사이트 the structure it uses to grapple the cells it infects.

They then closely studied 121 patients who recovered and donated their plasma 바카라 게임 웹사이트 once three months after they first developed symptoms and again five months later.

They saw a drop-off in some antibodies. But others persisted, they reported

"The serum antibody titer we measured in individuals initially were likely produced by plasmablasts, cells that act as first responders to an invading virus and come together to produce initial bouts of antibodies whose strength soon wanes," said Dr. Ania Wajnberg, director of Clinical Antibody Testing at the Mount Sinai Hospital.

"The sustained antibody levels that we subsequently observed are likely produced by long-lived plasma cells in the bone marrow. This is similar to what we see in other viruses and likely means they are here to stay. We will continue to follow this group over time to see if these levels remain stable as we suspect and hope they will."

Antibodies are not the only protection the immune system musters against infection, but they are an important first line of defense.

"Although this cannot provide conclusive evidence that these antibody responses protect from reinfection, we believe it is very likely that they will decrease the odds ratio of reinfection," the team wrote.

COVID-19 has been around for a only little under a year, so scientists are still learning about it. Stories of people becoming infected more than once are mostly anecdotal and few and far between.

There's obvious concern about this. It would be far better for getting rid of the pandemic if people developed permanent immunity to the virus after an infection. And, of course, immunity would be vital for a vaccine to work well.

It happens with other viruses. Measles is an example. One bout of measles usually leaves someone immune for life, an effect known as sterilizing immunity. The same was true for smallpox, before that virus was eradicated in the 1970s by a global vaccination campaign. And proper vaccination against measles and smallpox completely protects against infection.

But respiratory viruses such as influenza are trickier. People can catch flu over and over again and flu vaccines generally provide only partial protection against infection and severe disease. Part of that is due to flu's tendency to mutate.

Coronaviruses seem to fall in between. They can cause the common cold, but because they are not usually deadly, they are not as well studied. Until COVID-19's deadly cousin SARS came along, there was little interest in coronaviruses.

Still, there is evidence that people can and do develop some immunity to coronaviruses.

"We know from work with common human coronaviruses that neutralizing antibodies are induced, and these antibodies can last for years and provide protection from reinfection or attenuate disease, even if individuals get reinfected," Wajnberg and colleagues wrote.

"It is still unclear if infection with SARS-CoV-2 in humans protects from reinfection and for how long."

The next important step, they said, will be to establish what are known as correlates of protection. These are compounds that can be measured in the blood that will tell doctors whether someone is immune 바카라 게임 웹사이트 so that it won't be necessary to wait and see if they get infected again after one bout, or after getting a vaccine.